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 Post subject: PB1-F2
PostPosted: Thu Sep 03, 2009 10:54 am 
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from 1918 to 1947 H1N1 had a full PB1-F2, then since 1947 it
has a truncated PB1-F2 of length 57, so no mutation
at position 66 possible.

http://knol.google.com/k/vladimir-trifonov/the-contribution-of-the-pb1-f2-protein/

1947 was a severe season with a new variant appearing
and a total vaccine failure. Almost a pandemic but
mortality was low.
I remember a paper about reassortments in 1947(and 1951).

The truncated PB1-F2 had appeared after that ?
I think A/Fort Monmouth/1947(H1N1) was the pseudo-pandemic
strain and it had the full PB1-F2.

So...maybe rather than Mexflu acquiring the full PB1-F2
from seasonal H3N2, H3N2 may get the PB1 from Mexflu
and become less virulent...
Has it been tested ?


http://www.flutrackers.com/forum/showthread.php?t=37360

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 Post subject: Re: PB1-F2
PostPosted: Sun Sep 13, 2009 6:43 am 
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hours ago
PB1-F2 is mainly truncated in humans,swine,poultry while most wild birds
have a full PB1-F2. After some time of evolution outside wild birds
it may become reduced in length or get disfunctional.
http://www.setbb.com/fluwiki2/viewtopic.php?p=1901
So apparantly it is important in wild birds but not in mammals, poultry.
Where are poultry different from wild birds ? Anatomy is the same, so
presumably it's the way of living, the spread of the virus.
For wild birds fecal-oral is important while for mammals,poultry it's
repiratory ? For wild birds it spreads by flying. Someone please test
why a truncated PB1-F2 is bad for wild birds ...

Now, the idea is to help the virus a bit, truncate PB1-F2 in humans so it
spreads better and outcompetes old H3N2 (if mexflu should fail to do this...)
but at the same time also becomes less virulent.
Hey, the idea is to create a flu as mild as a cold :-) but also as frequent :-(
Flu alone is not so much interested to do this, if we don't help it,
it's just interested in wild birds, where it reassorts like crazy

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 Post subject: Re: PB1-F2
PostPosted: Wed Sep 16, 2009 6:50 pm 
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Interesting perspectives! And a great question!

Tell me off hand, what amino acids are produced in those that have the truncation to those that do not? Can you list those codons for me in frame? I cant do any alignments until this weekend.

That may lead you to the answer of your question?

NCBI came out this week with a lot of new sequences out of wisconsin it was nice to see everything sequenced instead of just HA.
I normally work in proteins and pathogens so a bit in unfamiliar water:)
Pandemic is giving me a crash course
;)


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 Post subject: Re: PB1-F2
PostPosted: Wed Sep 16, 2009 6:52 pm 
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PB1-F2 truncated in wild birds,
not "bad' but perhaps not "needed"?


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 Post subject: Re: PB1-F2
PostPosted: Wed Sep 16, 2009 6:58 pm 
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Posts: 893
Ok ok catching up here
http://www.virology.ws/2009/08/28/influ ... l-fitness/

http://www.virology.ws/2009/05/02/influ ... ce-marker/

"Curiously, all the relatives of the 2009 H1N1 strain in swine and in humans encode a complete PB1-F2 protein"

VERY INTERESTING subject!
Thanks:)


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 Post subject: Re: PB1-F2
PostPosted: Thu Sep 17, 2009 5:04 am 
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we had a thread here:
http://www.singtomeohmuse.com/viewtopic ... sc&start=0

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 Post subject: Re: PB1-F2
PostPosted: Thu Sep 17, 2009 6:04 am 
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Code:

>A/mexflu/index/2009/02/01(H1N1)
ATGGATGTCAATCCGACTCTACTTTTCCTAAAAATTCCAGCGCAAAATGCCATAAGCACCACATTCCCTTATACTGGAGATCCTCCATACAGCCATGGAACAGGAACAGGATACACCATGGACACAGTAAACAGAACACACCAATACTCAGAAAAGGGAAAGTGGACGACAAACACAGAGACTGGTGCACCCCAGCTCAACCCGATTGATGGACCACTACCTGAGGATAATGAACCAAGTGGGTATGCACAAACAGACTGTGTTCTAGAGGCTATGGCTTTCCTTGAAGAATCCCACCCAGGAATATTTGAGAATTCATGCCTTGAAACAATGGAAGTTGTTCAACAAACAAGGGTAGATAAACTAACTCAAGGTCGCCAGACTTATGATTGGACATTAAACAGAAATCAACCGGCAGCAACTGCATTGGCCAACACCATAGAAGTCTTTAGATCG...
>A/Wisconsin/10/98(H1N1)
ATGGATGTCAATCCGACTCTACTTTTCCTAAAAGTTCCAGCGCAAAATGCCATAAGCACCACATTCCCTTATACTGGAGATCCTCCATACAGCCATGGAACAGGAACAGGATACACCATGGACACAGTCAACAGAACACACCAATATTCAGAAAAGGGGAAGTGGACGACAAACACAGAGACTGGGGCACCCCAGCTCAACCCGATTGATGGACCACTACCTGAGGATAATGAACCAAGTGGATATGCACAAACAGACTGTGTTCTGGAGGCCATGGCTTTCCTTGAAGAATCCCACCCAGGGATATTTGAGAATTCATGCCTTGAAACAATGGAAGTTGTTCAACAAACAAGGGTGGATAAACTAACTCAAGGTCGCCAGACTTATGATTGGACATTGAACAGAAATCAACCGGCAGCAACTGCATTGGCCAACACCATAGAAGTTTTTAGATCG...
                                 x                                                                                              }                                                        x                                                        x                       }     x                             x                                                     }                                         x                                               x
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>A/mallard duck/South Dakota/Sg00125/2007(H3N2)
---------------ACTCTACTTTTTCTAAAGGTTCCAGCGCAAAATGCCATAAGCACCACATTCCCTTATACTGGAGATCCTCCATACAGCCATGGAACAGGAACAGGATACACCATGGACACAGTCAACAGAACACACCAATATTCAGAAAAAGGGAAGTGGACGACAAACACAGAGACTGGGGCACCCCAGCTCAACCCGATTGATGGACCACTACCTGAGGATAATGAACCAAGTGGATATGCACAAACAGACTGTGTTCTGGAGGCCATGGCTTTCCTTGAAGAATCCCACCCAGGGATATTTGAGAATTCATGCCTTGAAACAATGGAAGTTGTTCAACAAACAAGGGTGGATAAACTAACTCAAGGTCGCCAGACTTATGATTGGACATTAAACAGAAATCAACCGGCAGCAACTGCATTGGCCAACACCATAGAAGTTTTTAGATCG...



>A/Brevig Mission/1/1918(H1N1)
PB1,758,MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSEKGRWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHPGIFENSCLETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLTANESGRLIDFLKDVMESMDKEEMEITTHFQRKRRVRDNMTKKMVTQRTIGKKKQRLNKRSYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYITRNQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQIPAEMLASIDLKYFNDSTRKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQKRYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLLGINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFEIKKLWEQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPFVSHKEIESVNNAVMMPAHGPAKNMEYDAVATTHSWIPKRNRSILNTSQRGILEDEQMYQKCCNLFEKFFPSSSYRRPVGISSMVEAMVSRARIDARIDFESGRIKKEEFAEIMKICSTIEELRRQK}
PB1-F2,91,MGQEQDTPWILSTGHISTQKREDGQQTPRLEHHNSTRLMDHCQKTMNQVVMPKQIVYWKQWLSLRSPTPVSLKTRVLKRWRLFSKHEWTS}

>A/Mexflu/index/2009-02-01
PB1,757,  MDVNPTLLFLKIPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSEKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHPGIFENSCLETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLTANESGRLIDFLKDVMESMNKEEIEITTHFQRKRRVRDNMTKKMVTQRTIGKKKQRLNKRGYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTEISFTITGDNTKWNENQNPRMFLAMITYITRNQPEWFRNILSMAPIMFSNKMARLGKGYMFESKRMKIRTQIPAEMLASIDLKYFNESTKKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQKKYTKTIYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLVGINMSKKKSYINKTGTFEFTSFFYRYGFVANFSMELPSFGVSGVNESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFELKKLWDQTQSKVGLLVSDGGPNLYNIRNLHIPEVCLKWELMDDDYRGRLCNPLNPFVSHKEIDSVNNAVVMPAHGPAKSMEYDAVATTHSWIPKRNRSILNTSQRGILEDEQMYQKCCNLFEKFFPSSSYRRPVGISSMVEAMVSRARIDARVDFESGRIKKEEFSEIMKICSTIEELRRQK}
PB1-F2,90,MEQEQDTPWTQ}TEHTNTQKRESGRQTQRLVHPSSTRLMDHYLRIMNQVGMHKQTVF}RLWLSLKNPTQEYLRIHALKQWKLFNKQG}IN}

>A/mallard duck/South Dakota/Sg00125/2007(H3N2)
PB1:-----TLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSEKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHPGIFENSCLETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLTANESGRLIDFLKDVMESMDKEEIEITTHFQRKRRVRDNMTKKMVTQRTIGKKKQRVNKRGYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYITRNQPEWFRNILSMAPIMFSNKMARLGKGYMFESKRMKLRTQIPAEMLASIDLKYFNESTRKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQKKYTRTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLVGINMSKKKSYINKTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFELKKLWDQTQSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYRGRLCNPLNPFVSHKEIDSVNNAVVMPAHGPAKSMEYDAVATTHSWIPKRNRSILNTSQRGILEDEQMYQKCCNLFEKFFPSSSYRRPVGISSMVEAMVSRARIDARIDFESGRIKKEEFSEIMKICSTIEELRRQK}---------
PB1-F2:MEQEQDTPWTQSTEHTNIQKKGSGRQTQRLGHPSSTRLMDHYLRIMNQVDMHKQTVFWRPWLSLKNPTQGYLRIHALKQWKLFNKQGWIN}LKVARLMIGH}TEINRQQLHWPTP}KFLDRMV}QLMSQEG}}IS}RM}WNQWIKRK}R}QHTFKEKGE}ETT}PRRWSHKEQ}ERKNKE}IREVI}}EH}H}IR}PKMQREAN}KEGLSQHLGCKLEGSCTLLKL}LGAFAKSLNSLDSQ}GAMKRKPNWQML}ER}}LIHKTQSFLSQSLGTTLSGMKIKILECSWR}LHISPEINPSGSETS}AWHP}CSQTKWQD}EKGTCSRVKE}SSEHKYQQKC}QALT}SISMNQQGRKLRK}GLF}}MAQHH}ALE}}WACSTC}VRFWESRY}ILDKRNTPGQHTGGMDSNPPTILPS}}MHQIMREYKQEWIDSTGPAS}WEST}AKRSPI}IRQGHLNSQAFFIAMDLWLILAWSCPVLECLE}MNQLI}VLE}Q}}RTT}}TMTLDLQQPRWPFNCSSKTTDTHIGAIEETHKFRREDHSS}RSCGIKPNQRQDY}YLMEDQTYTISGIFTFLRSA}NGS}WMRIIGEDFVIP}TPLSAIKRLIL}TMLW}CQPMVQPKAWNMMPLQLHTPGFPRGTALFSTQAKGEFLRMNRCTRSAATCSRNFSLVVHTGDRLEFLAWWRPWCLGPGLMPGLTSSLDGLRKKSSLRS}RSVPPLKNSDGKN----------

>A/Wisconsin/10/98(H1N1)
PB1:MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSEKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHPGIFENSCLETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLTANESGRLIDFLKDVMESMDKEEIEITTHFQRKRRVRDNMTKKMVTQRTIGKKKQRVNKRGYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYITRNQPEWFRNILSMAPIMFSNKMARLGKGYMFESKRMKLRTQIPAEMLASIDLKYFNESTRKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQKKYTRTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLVGINMSKKKSYINKTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFELKKLWDQTQSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYRGRLCNPLNPFVSHKEIDSVNNAVVMPAHGPAKSMEYDAVATTHSWIPKRNRSILNTSQRGILEDEQMYQKCCNLFEKFFPSSSYRRPVGISSMVEAMVSRARIDARIDFESGRIKKEEFSEIMKICSTIEELRRQK}---------
PB1-F2:MEQEQDTPWTQSTEHTNIQKRGSGRQTQRLGHPSSTRLMDHYLRIMNQVDMHKQTVFWRPWLSLKNPTQGYLRIHALKQWKLFNKQGWIN}LKVARLMIGH}TEINRQQLHWPTP}KFLDRMV}QLMSQEG}}IS}RM}WNQWIKRK}R}QHTFKEKGE}ETT}PRRWSHKEQ}ERKNKE}IREVI}}EH}H}IR}PKMQREAN}KEGLSQHLGCKLEGSCTLLKL}LGAFAKSLNSLDSQ}GAMKRRPNWQML}ER}}LIHKTQSFLSQSLGTTLSGMKIKILECSWR}LHISPEINPSGSETS}AWHP}CFQTKWQD}EKGTCSRVKE}SSEHKYQQKC}QALT}SISMNQQGRKLRK}GLF}}MAQHH}ALE}}WACSTC}VRFWESRY}ILDKRNTPGQHTGGMGSNPPTILPS}}MHQIMREYKQEWIDSTGPAS}WEST}AKRSPI}IRQGHLNSQAFFIAMDLWLILAWSCPVLECLE}MNQLI}VLE}Q}}RTT}}TMTLDLQQPRWPFNCSSKTTDTHIGAIEETHKFRREDHSS}RSCGIKPNQRQDY}YLMEDQTYTISGIFTFLKSA}NGS}WMRIIGEDFVIP}IPLSAIKRLIL}TMLW}CQPMVQPKAWNMMPLQLHTPGFPRGTALFSTQAKGEFLRMNRCTRSAATCSRNFSLVVHTGDRLEFLAWWRPWCLGPGLMPGSTSSLDGLRKKSSLRS}RSVPPLKNSDGKN----------

PB1-F2:
MGQEQDTPWILSTGHISTQKREDGQQTPRLEHHNSTRLMDHCQKTMNQVVMPKQIVYWKQWLSLRSPTPVSLKTRVLKRWRLFSKHEWTS}
MEQEQDTPWTQ}TEHTNTQKRESGRQTQRLVHPSSTRLMDHYLRIMNQVGMHKQTVF}RLWLSLKNPTQEYLRIHALKQWKLFNKQG}IN}
MEQEQDTPWTQSTEHTNIQKKGSGRQTQRLGHPSSTRLMDHYLRIMNQVDMHKQTVFWRPWLSLKNPTQGYLRIHALKQWKLFNKQGWIN}
MEQEQDTPWTQSTEHTNIQKRGSGRQTQRLGHPSSTRLMDHYLRIMNQVDMHKQTVFWRPWLSLKNPTQGYLRIHALKQWKLFNKQGWIN}
           x                                             x                             x  x
32         43                 .                  .       89         100


mex :MDVNPTLLFLKIPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSEKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHPGIFENSCLETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLTANESGRLIDFLKDVMESMNKEEIEITTHFQRKRRVRDNMTKKMVTQRTIGKKKQRLNKRGYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTEISFTITGDNTKWNENQNPRMFLAMITYITRNQPEWFRNILSMAPIMFSNKMARLGKGYMFESKRMKIRTQIPAEMLASIDLKYFNESTKKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQKKYTKTIYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLVGINMSKKKSYINKTGTFEFTSFFYRYGFVANFSMELPSFGVSGVNESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFELKKLWDQTQSKVGLLVSDGGPNLYNIRNLHIPEVCLKWELMDDDYRGRLCNPLNPFVSHKEIDSVNNAVVMPAHGPAKSMEYDAVATTHSWIPKRNRSILNTSQRGILEDEQMYQKCCNLFEKFFPSSSYRRPVGISSMVEAMVSRARIDARVDFESGRIKKEEFSEIMKICSTIEELRRQK}
wisc:MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSEKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHPGIFENSCLETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLTANESGRLIDFLKDVMESMDKEEIEITTHFQRKRRVRDNMTKKMVTQRTIGKKKQRVNKRGYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYITRNQPEWFRNILSMAPIMFSNKMARLGKGYMFESKRMKLRTQIPAEMLASIDLKYFNESTRKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQKKYTRTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLVGINMSKKKSYINKTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFELKKLWDQTQSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYRGRLCNPLNPFVSHKEIDSVNNAVVMPAHGPAKSMEYDAVATTHSWIPKRNRSILNTSQRGILEDEQMYQKCCNLFEKFFPSSSYRRPVGISSMVEAMVSRARIDARIDFESGRIKKEEFSEIMKICSTIEELRRQK}---------
                x


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 Post subject: Re: PB1-F2
PostPosted: Thu Sep 17, 2009 6:21 am 
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Location: germany
so, it's just 2 or 3 synonymous mutations which would generate
a full-length PB1-F2 similar in amino-acids to the 1998
ancestor viruses (birds-->humans(1968)-->swine(1995)-->humans(2009) )

but during 1998-2009 these mutations were "lost" creating
a non-functional PB1-F2, so I assume the nonfunctional version is
better in swine and humans, or at least PB1-F2 has no advantage
in humans and swine here.

Else these two synonymous mutations could easily be done ?!?

--------------

mexflu has 7 amino-acid differences to Wisconsin/10/98
but these changes are synonymous in PB1, don't change PB1,
so it's apparantly not PB1 that forced this evolution by selection


create a seasonal H3N2 virus with defect PB1-F2
and test it in the lab ! Has it disadvantages compared with
the original virus ? Is it less virulent ?

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 Post subject: Re: PB1-F2
PostPosted: Thu Sep 17, 2009 1:05 pm 
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Well I would say it could go either way depending on assortment. Dont forget seasonal has a high resistance to Tamiflu and that would also skew numbers a bit.

Something which is standing out to me, is the oddity of having three stop codons
in PB1 of this novel H1N1 when that is to my knowledge almost unheard of in most strains of H1N1. Doesnt that strike you as a bit odd? Do you have a hypothesis for that?

We are told 1918 strain had full length, and it added to its 'virulence' at that time.

So my question would be, where are the sequences for those that are dying in what appear to be cytokine storm? Do we have any PB1 sequences coming out of Brazil right now? Hopefully I will get more time to do some sorting tonight.
There seems to be a lot of "missing sequences" on NCBI right now.

Its also very frustrating as I can not tell which sequences were from someone with sniffles to which sequences caused cytokine storm or rapid death.
That information is really important to understanding how this thing is going to go and what we are dealing with. Have you found ANY way to match the clinical findings of the patient with a specific sequence?

We could be wasting a lot of time on sequences which only resulted in sniffles and nothing more. And worse it could cause miss direction and bad assumptions. :banghead:

:scratch:


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 Post subject: Re: PB1-F2
PostPosted: Thu Sep 17, 2009 2:01 pm 
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Posts: 1533
Location: Northern California
TheHappyScientist wrote:
Well I would say it could go either way depending on assortment. Dont forget seasonal has a high resistance to Tamiflu and that would also skew numbers a bit.

Something which is standing out to me, is the oddity of having three stop codons
in PB1 of this novel H1N1 when that is to my knowledge almost unheard of in most strains of H1N1. Doesnt that strike you as a bit odd? Do you have a hypothesis for that?

We are told 1918 strain had full length, and it added to its 'virulence' at that time.

So my question would be, where are the sequences for those that are dying in what appear to be cytokine storm? Do we have any PB1 sequences coming out of Brazil right now? Hopefully I will get more time to do some sorting tonight.
There seems to be a lot of "missing sequences" on NCBI right now.

Its also very frustrating as I can not tell which sequences were from someone with sniffles to which sequences caused cytokine storm or rapid death.
That information is really important to understanding how this thing is going to go and what we are dealing with. Have you found ANY way to match the clinical findings of the patient with a specific sequence?

We could be wasting a lot of time on sequences which only resulted in sniffles and nothing more. And worse it could cause miss direction and bad assumptions. :banghead:

:scratch:

You go get them and find the answers for us. Thank you for your hard work on this, I do not really understand you "scientist" talk, but I am reading within the lines. Keep us posted, you are great.


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