wotan wrote:
Here's where I am going with this. We know that D225G and D225N have both been associated with severe lung involvement. They may, however, attack different locations in the lungs. Similarly, wild-type and D225E apparently attack upper portions of the respiratory tract. We have seen instances where D225G (and N?) has been found in the mid to upper respiratory tract. And we have patients apparently infected with multiple types.
So, perhaps someone is infected with multiple types, and they reach the areas that they preferentially infect, but those overlap, allowing G and N to to mix, recombine possibly, and as new virions are released some of them may rise a little higher, mixing with E and wild-type, and by this method the D and N polymorphisms are allowed to survive and spread. In some instances one or both of these becomes dominant in an individual and the viral load in the lungs is driven up, leading to the more severe infections. And perhaps because they are so virulent when present in large quantities, that might explain why you won't necessarily see multiple members of the same family suffering in the same way.
Ah, ok, so the idea is that several viruses are mixed together and spreading together, and maybe shuffling the deck back and forth while inside someone. Ok, that makes sense. How come no one mentioned it up to now?
Mixtures have been mentioned since day 1, including California/7, which is the vaccine target and has wild type D225 as well as D225G.
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