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PostPosted: Wed Dec 30, 2009 3:44 pm 
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now you have 3 (out of >3000)
so why would recombination avoid the other 3000 ?

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PostPosted: Wed Dec 30, 2009 4:15 pm 
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gsgs wrote:
now you have 3 (out of >3000)
so why would recombination avoid the other 3000 ?

You really don't understand. D225G and D225N are RARE and are only in about 1% of the sequences, so getting them both in the same cell is even rarer. Recombination and evolution build upon the available sequences. When such sequences are rare, combinations involving two rare events are even rarer.

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PostPosted: Wed Dec 30, 2009 4:54 pm 
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To get them both into the same cell, would this not also imply that the population of D225G and D225N "carriers" (probably not the right word, but the meaning is hopefully clear) is much higher than previously thought?


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PostPosted: Wed Dec 30, 2009 4:57 pm 
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I presume the answer to my last question is "no," and that the recombination occurs naturally within the body and so there are no need for "carriers" per se?


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PostPosted: Wed Dec 30, 2009 5:05 pm 
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Pandora wrote:
To get them both into the same cell, would this not also imply that the population of D225G and D225N "carriers" (probably not the right word, but the meaning is hopefully clear) is much higher than previously thought?

Contrary to the ECDC/WHO proclamation, D225G/N transmits so once both viruses are in the same host they can transmit together (and the presence of both together probably offers a selective advantage).

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