Rhiza Labs FluTracker Forum

The place to discuss the flu
It is currently Fri Apr 28, 2017 5:55 pm

All times are UTC - 5 hours [ DST ]




Post new topic Reply to topic  [ 5 posts ] 
Author Message
PostPosted: Fri Aug 28, 2009 7:54 am 
Offline

Joined: Wed Aug 19, 2009 10:42 am
Posts: 56044
Location: Pittsburgh, PA USA
http://www.recombinomics.com/News/08280 ... 4Y_CA.html

Tamiflu Resistance in Northern California
Recombinomics Commentary 12:42
August 28, 2009


During this week, the CDPH Viral and Rickettsial Diseases Laboratory detected a specimen with the H275Y resistance mutation (associated with oseltamivir resistance); the result was confirmed by the CDC. This is the first time that this mutation has been detected by the VRDL and provides strong evidence for the importance of enhanced surveillance for antiviral resistance testing. The specimen was obtained from a hospitalized patient in Northern California.

The above comments are from the latest report from the California Department of Public Health and may be the first example of a hospitalized patient in the US who has H274Y and is not immuno-compromised. Earlier two immuno-compromised cancer patients were described in Seattle, in addition to two summer campers in North Carolina who were on prophylactic Tamiflu

Earlier a traveler from San Francisco was H274Y positive in Hong Kong, and had no reported Tamiflu exposure, raising concerns of an evolutionarily fit pandemic H1N1 circulating in northern California, since the infected travel was symptomatic during or shortly after deplaning form a non-stop flight originating in San Francisco.

The above description does not include Tamiflu use in the hospitalized patient, so it is unclear if the H274Y was detected prior to treatment or if treatment selected for H274Y. Prior cases developed resistance shortly after the start of treatment, raising concerns of H274Y circulation as minor component in worldwide infections, leading to increases in deaths as seen in California, or widespread outbreaks as seen in schools in the southern United States.

Moreover, the number of cases of resistance continues to rise. The latest WHO update on reported cases cites four for Japan, indicating another patient on prophylactic Tamiflu developed an infection which was H274Y positive.

More information on Tamiflu exposure linked to the hospitalized patient in northern California, as well as sequence data on the growing number of H274Y positive cases would be useful.

_________________
www.twitter.com/hniman


Top
 Profile  
 
PostPosted: Sat Aug 29, 2009 10:52 pm 
Offline

Joined: Wed Aug 19, 2009 3:13 pm
Posts: 144
Has this mutated virus the same virulence than the previous form or is it stronger under one or the other aspect ?

_________________
LET THE SWISS HOSTAGES GO BACK HOME !
They are now back in the Swiss Ambassy of Tripoli.


Top
 Profile  
 
PostPosted: Sat Aug 29, 2009 11:05 pm 
Offline
User avatar

Joined: Tue Aug 11, 2009 2:58 pm
Posts: 1419
Location: Katy, TX
Suisse wrote:
Has this mutated virus the same virulence than the previous form or is it stronger under one or the other aspect ?


As yet we know nothing about this patient,or the other 2 cases of Tamiflu resistance announced by the CDC this week.

_________________
I am not a doctor, virologist, or any of type of medical/life sciences professional.

I am a layman with a background in the physical sciences.


Top
 Profile  
 
PostPosted: Sun Aug 30, 2009 6:09 am 
Offline

Joined: Wed Aug 19, 2009 10:42 am
Posts: 56044
Location: Pittsburgh, PA USA
wotan wrote:
Suisse wrote:
Has this mutated virus the same virulence than the previous form or is it stronger under one or the other aspect ?


As yet we know nothing about this patient,or the other 2 cases of Tamiflu resistance announced by the CDC this week.

I suspect this virus is evolutionarily fit and can cause hospitalizations. In the CDC weekly report, only 1 sample was being investigated for prior Tamiflu use, and the above case was a hospitalized patient. If it was from a patient on prophylatic Tamiflu, they should have known prior to the CDC report. I suspect this sample was from a hospitalized patient and discovered after the fact by routine surveillance, so they have to go back to the records to see when or if the patient started tamiflu (and relationship to date of samples collection).

_________________
www.twitter.com/hniman


Top
 Profile  
 
PostPosted: Mon Sep 28, 2009 9:36 pm 
Offline

Joined: Fri Sep 04, 2009 2:57 pm
Posts: 237
Northern California is huge. San Francisco is considered NoCal, but is 3-4 hours south of us, in the real, NoCal. A more specific location would be nice. sgrondahl


Top
 Profile  
 
Display posts from previous:  Sort by  
Post new topic Reply to topic  [ 5 posts ] 

All times are UTC - 5 hours [ DST ]


Who is online

Users browsing this forum: No registered users and 4 guests


You cannot post new topics in this forum
You cannot reply to topics in this forum
You cannot edit your posts in this forum
You cannot delete your posts in this forum
You cannot post attachments in this forum

Search for:
Jump to:  
cron
Powered by phpBB® Forum Software © phpBB Group