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This translation also cites influenza, but it remain unclear if this translation is accurate (or if adenovirus is being cited as being common, like influenza).

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2009 article describing lung damage by H1N1 (soundslike fatal Pennsylvania case (11F)

The new pandemic H1N1 flu may cause blood clots and other unusual damage in the lungs and doctors need to be on the lookout, U.S. researchers reported on Thursday.

Two studies published in the American Journal of Roentgenology show the need to check X-rays and CT scans for unusual features, and also point out swine flu can be tricky to diagnose in some of the sickest patients.

H1N1 flu is causing a pandemic, and while it is not particularly deadly, it is sickening many younger adults and older children who usually escape the worst effects of seasonal flu.

"It is therefore essential that clinicians be able to recognize possible cases of pandemic H1N1 influenza in high-risk groups so that they order the appropriate diagnostic tests, begin specific antiviral therapy, and prepare to provide intensive supportive measures as needed," Dr. Daniel Mollura of the National Institutes of Health Clinical Center in Maryland and colleagues wrote.

Full Coverage H1N1: Click here

LiveShots Blog: H1N1

One middle-aged man who died was not diagnosed until after death, but unusual findings on his X-rays may be able to help doctors save other, similar patients.

Mollura's team found irregularities called ground-glass opacities in the patient's lungs using a CT scan. Although the patient was severely ill and had a fever, he tested negative for flu and doctors did not treat him for it.

The man died five days after he went into the hospital and the autopsy confirmed he had swine flu. The lung lesions seen on his CT scan matched lung damage done by the virus, Mollura and colleagues said.

In another study in the same journal, CT scans of patients with severe cases of swine flu showed many had pulmonary emboli, which block the arteries in the lungs, a team at the University of Michigan found.

Anticoagulant drugs can break up these clots and save lives.

Dr. Prachi Agarwal and colleagues examined 66 patients diagnosed with H1N1, 14 of them who were in the intensive care unit. All 66 got standard X-rays, which can show if a patient has pneumonia.

They performed enhanced X-rays known as computed tomography or CT scans on 15 of the patients, 10 of them who were in the ICU on ventilators to help them breathe. Five of the ICU patients had the blood clots in the lungs, Agarwal reported

"Our study suggests that patients who are severely ill with H1N1 are also at risk for developing pulmonary emboli, which should be carefully sought for on contrast-enhanced CT scans," Agarwal said in a statement.

"The majority of patients undergoing chest X-rays with H1N1 have normal radiographs (X-rays)," she added. Pulmonary emboli are also not normally seen in flu, she said.

"CT scans proved valuable in identifying those patients at risk of developing more serious complications as a possible result of the H1N1 virus, and for identifying a greater extent of disease than is appreciated on chest radiographs."

http://www.foxnews.com/story/0,2933,567460,00.html

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Note similarities with other H1N1 cases as well as "mystery virus".

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machine translation -

Pregnant women flu rise to a "honeycomb lung" death trap, Seoul Hospital, fear the unknown virus
<"News article list2011-5-14 China Daily


Consolidated foreign media reports on May 12, Seoul, South Korea, a hospital caused by a virus appears strange suspected disease, seven patients have been produced or all pregnant women about to give birth and now has a woman was killed and six people are hospitalized treatment.　　Korea Center for Disease Control and Prevention through May 10 revealed that a 36-year-old, pregnant women have been the day of 9 months in the early morning death of a general hospital in Seoul. The deceased April 8 Zengyin sick to the hospital, was diagnosed with pulmonary tuberculosis. The three-day medication therapy is not effective, further deterioration of women's disease, was admitted to the ICU. The hospital into its line of premature surgery, so she received further treatment.
　　But in the delivery after the patient's pulmonary tuberculosis in a very short period of time to change for the pulmonary fibrosis , simultaneous cerebral hemorrhage symptoms and eventually death. The so-called pulmonary fibrosis is the proliferation of mesenchymal cells in the lung, a large amount of collagen and extracellular matrix, the normal structure of lung tissue is replaced by cystic cavity, to the late development of this disease will be presented throughout the honeycomb lung.
　　Even more alarmed that the hospital, the hospital's other six have been produced or the labor of pregnant women had the same symptoms.
　　South Korean officials said that at present no law sure that this is virus, but can determine the speed of its spread seems unhappy. Korea Center for Disease Control and Prevention have been from the dead and six patients were extracted sample has not found cause of death unknown viruses. An official of the Centre, said: "sample DNA testing also need more time. We extracted samples from the dead is a common flu viruses like HIV, but we need better understanding of what led to pulmonary fibrosis. "　　The official said, "it is necessary to clarify whether this is a new variant of the virus. We will conduct further tests to determine the cause of this woman's real cause of death, but also by analyzing the remaining patients, including food and living environment Other factors that determine the causes of these symptoms. "

Picture of "honeycomb lung" phenomena:


http://library.med.utah.edu/WebPath/LUN ... NG097.html

http://www.koreaherald.com/national/Det ... 0623000599

Mom, two daughters stricken by mysterious lung disease


At 0:30 on Sunday morning, Jin-ju finally stopped breathing.

It was the 93rd day since the 15-month-old baby girl had been hospitalized with flu-like symptoms, which turned out to be an unidentified acute lung disease that has claimed the lives of four patients since May.

“I went to Busan (where she was hospitalized) upon hearing the news, had her cremated and came back,” Jeon Hyo-taek, the father, told The Korea Herald on Tuesday outside Asan Medical Center in Seoul. In Korea, when a baby that young dies, he or she is usually cremated without any funeral service.

Jeon, an army officer, was calm and showed little emotion as he spoke. But when he tried to show mobile phone pictures of his beloved girl, his hands trembled.

He will mourn for Jin-ju later, he said. Now, he has a wife and another daughter to care for.

In intensive care units here at Asan, his 32-year-old wife Baek Hyun-jung and 6-year-old daughter Ju-young are struggling for their lives. Both are battling the same mysterious disease that took Jin-ju’s life.

Jeon’s family is the first reported case in which members of the same family have caught the disease. In the past two months, eight patients have been confirmed stricken with the disease that causes severe scarring and thickening of lung tissue. Seven of them were expecting or recently gave birth. Four of them died.

“At first, we didn’t know what was happening,” Jeon said.

Jin-ju first developed the symptoms ― coughing and difficulty breathing ― around the middle of March. Soon after, her mother and Ju-young showed similar symptoms and were hospitalized at the same hospital with Jin-ju in Busan.

On June 7, the mom and older child were transferred to Asan, where other patients with the disease are receiving treatment. By that time, Jin-ju’s condition had deteriorated to a point where she wasn’t able to make the transfer.


...more at link .....


and the ending ......

In a local journal of pediatrics, there were reports of 15 cases among children between March and June in 2006, and they were then categorized as “acute interstitial pneumonia.” Seven of the 15 died within two months after admission to hospital. More were reported in 2008, with a similarly high mortality rate.

Acute interstitial pneumonia typically causes rapid pulmonary fibrosis, or severe scarring and thickening of the lung tissue, but the cases mentioned above and the recent cases involved scarring of airway tissue as well, he explained.

“We need further study to determine whether it was the same disease,” he said.

The KCDC plans a longer-term study which may last more than three years, to investigate it.

If it were contagious, the disease should have been found in those with a weak immune system like the elderly, infants and chronic invalids, but there was no such case, the KCDC explained.

The assurance, however, seems to be failing to allay the public fears as another suspected case of an outbreak within a family was reported.

Last week, an expectant mom and her 3-year-old son were found to have contracted the disease, in what could be the second case of an outbreak among family members.

From memory, they claimed they tested for flu and found nothing?

Bad testing or not flu?