Rhiza Labs FluTracker Forum

edited to change title from 'Spain reports mutant swine flu death - Andalusia'
to more general Spain reports on mutations in D222


http://translate.google.com/translate?j ... l=es&tl=en


A man aged 31 died today in Andalusia as a result of a mutation of the N1H1 virus. This is the second death in the Spanish State by mutation of influenza A.

In the rest of Europe, influenza A is causing fewer problems than expected, result has been a surplus of vaccine.
The governments of France and the Netherlands have begun selling vaccines abroad and the Government of Spain could begin to do the same within a short period of time.

Spanish version
http://www.elpais.com/articulo/sociedad ... usoc_9/Tes

google translation of excerpt relating to a D222G mutation

On the other hand, a man aged 31 has died in Andalusia by complications from a mutation of the influenza virus A, D222G, which makes it the second death in Spain by this alteration of the H1N1 virus detected at a time first in Norway, as reported in its latest weekly report from the National Epidemiological Surveillance Network of the Instituto de Salud Carlos III. This patient, who had no medical history, eventually dying of multiple organ failure after several complications, reports the monitoring system sentinel physicians, which however does not specify the time of death. However, Health Ministry sources say that this mutation is "expected" behavior according to each year have the flu virus. This mutation has been detected in other countries around the world, although its significance is not fully defined, could enhance the virus would "infect it easier to lower areas of the respiratory tract, the Surveillance Network reported in its latest report, on the week of 20 to 26 December.

A man aged 31 on Monday has become the second fatality for complications resulting from a mutation of the influenza virus A. The man, who died in Andalusia, had no medical background.


http://www.cope.es/sociedad/04-01-10--s ... a-121859-1

Second death from influenza A mutation in Spain

A man aged 31 on Monday has become the second fatality for complications resulting from a mutation of the influenza virus A, 'D222G', first detected in Norway, as reported in its latest weekly national network Epidemiological Surveillance of the Health Institute Carlos III.

The man, who died in Andalusia, had no medical background. The Carlos III Health Institute has recorded nearly half a hundred cases of mutation of the influenza virus A.

The patient eventually dying of multiple organ failure after several complications. However, sources from the Ministry of Health and Social Policy ensures that this mutation is "expected" behavior according to each year have the flu virus.

This mutation has been detected in other countries around the world, although its significance is not fully defined, could enhance the virus would "infect it easier to lower areas of the respiratory tract.

The first fatality in this mutation was released on 4 December, a woman 35 years of Catalonia with associated pathologies that eventually died after being in serious condition.

Moreover, these two deaths have to add three more cases of this same mutation in the H1N1 virus, one in a man of 31 years of Catalonia, which evolved without problems, in Castilla-La Mancha in a woman of 28 years and another in Galicia, a man of 27 years, the last two without knowledge of risk factors.

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I think this says that they are reporting 5 additional mutations - two that died, the first December 4th and the 2nd on January 4th, and three more - a man of 31 years, a woman of 28 years and a man of 27 years.

January 6, 2010
In Melilla [ Spain] have also detected a mutation in patients with influenza A virus.

http://translate.googleusercontent.com/ ... YUk8F8UQpA

First case of virus mutation Influenza A in Melilla

The National Epidemiological Surveillance Network has discovered a mutation of the influenza virus A, D222G, which the National Microbiology Center (NMC) has found its presence in 34 patients, one of Melilla. Castilla-La Mancha, Ceuta, Galicia, Madrid, Navarra. Andalusia and Asturias has also been identified in patients. This mutation has been detected in other countries around the world, although its significance is not fully defined, could favor the virus were 'easier to infect lower areas of the respiratory tract, "the Surveillance Network reported in its latest report, on the week of 20 to 26 December. This mutation affects RNA virus envelope in a place near the junction of the receiver to the bronchial epithelial cell, although "the significance of this change in the receptor-binding site is highly questionable, 'the authors the report, "the data of patients who present can be of great help in trying to interpret if you have some functionality.
Furthermore, this center under the Carlos III also reports of two cases known as oseltamivir-resistant virus, the antiviral used to combat new flu Roche markets under the name 'Tamilfu'.
Pocas vacunas Few vaccines
Given these data, the Minister of Social Welfare and Health of the Autonomous City of Melilla regretted that vaccinations against influenza A virus in Melilla are being so low, since, according to data handled by Maria Antonia Garbín until currently only used 2,000 of the 12,000 vaccines that are available in the city.
While acknowledging that the dates of vaccination are "very bad", the adviser expects to launch an information campaign to encourage citizen prevention-risk groups.
For the time vaccines are available in all health centers both public and private, but in the event that finally it was never used this season, Garbín anticipated that all those responsible for the health of the various Spanish communities together to decide what do with the surplus. He reminded the adviser that the biggest problem is that the vaccine does not work from one year to another because the strain is different, although I trust that, with the upcoming and predictable falling temperatures, people valued the option of vaccination.



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different version of same story ..... the first one and the second one are inconsistent wrt which mutations are D225E and how many/where are D225G cases.

http://www.melillahoy.es/noticia/61754/ ... gripe.html




The National Epidemiological Surveillance Center of the Health Institute Carlos III reports that have already been registered in Spain more than 40 cases of mutations of the H1N1 virus that causes influenza, among which would be the "D222E", which has found its presence in 34 patients from Castilla-La Mancha, Ceuta, Galicia, Madrid, Melilla and Navarra. In addition, Andalusia and Asturias have identified in 6 and 1 cases respectively. In Melilla have been vaccinated only two thousand people, despite being available over twelve thousand doses.

Councilor Welfare and Health, Maria Antonia Garbin, said the [anti- vaccination campaign against influenza A] is doing "evil", and this is because even though it gained about twelve thousand doses have been distributed at health centers and insurance, just "two thousand people have been vaccinated. The figures are below the norm in the rest of the country. [I added the anti- I think that this is what was meant here]

Considers that one of the causes that are not vaccinated Melilla and also a decline in the number of infections, high temperatures are still found in Melilla. In fact according to the National Epidemiological Surveillance of the Health Institute Carlos III, the reported incidence rate of influenza is in Melilla in 28.18 cases per 100,000 population, below the national average which is 40.8 cases .

But Garbín said that we must not drop our guard, because from now is expected to reach the winter weather will cause an increase in flu cases. "We will continue the campaign until being told otherwise by health authorities.

A journalists' questions, said Garbín not yet decided what to do with leftover doses, and that decision will be adopted in the relevant body in Madrid with the participation of all communities. One solution that has considered is to send low-income countries. What is certain is that these vaccines will no longer be operational next year, driven by the mutation that is prone to the flu virus, both A and B.

Recognized Garbín have been detected in our country mutations of H1N1 (influenza virus) that are being analyzed by the Carlos III Institute, without which for the moment had been issued special rules to follow.

Mutations
Just this week a man aged 31 died in Andalusia from complications from a mutation of the influenza virus A, "D222G", becoming the second death in Spain by this alteration of the H1N1 virus first detected in Norway According to the latest weekly report from the National Epidemiological Surveillance Network.

This patient, who had no medical history, eventually dying of multiple organ failure after several complications, reports the monitoring system by Sentinel Physicians. However, Health Ministry sources claimed that this mutation is "expected" behavior according to each year have the flu virus.

This mutation has been detected in other countries and, although its significance is not fully defined, could enhance the virus would "infect it easier to lower areas of the respiratory tract, the Surveillance Network reported in its latest report.

In addition, the National Epidemiological Surveillance Network reported more than 40 mutations of "D222E" and that his presence was found in about 34 patients from the regions of Castilla-La Mancha, Ceuta, Galicia, Madrid, Melilla and Navarra.


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Spain seems to be more upfront about discussing the strains of virus that show mutations. They have reported two deaths, both with the D225G change, and 40 (in 34 patients?) mutations with D225E with no deaths reported.

January 8th update -


http://www.farodevigo.es/sociedad-cultu ... 01503.html

Influenza refers in Galicia

(article mostly gives info on flu stats. I have excerpted only the info on the D222E and D225G)




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so 2 deaths out of 10 with D222G in Spain.

This article is quite specific on ‘site 222’ [H3 HA 225] different ‘mutations’:

http://www.adn.es/lavida/20100104/NWS-1 ... uerte.html


From the text above, we have a total of 5 'D222G' (which I assume to be H3 HA D225G) ,
2 fatal (1 F 35 +1 M 31), 1 recovered (M 31), and 2 cases (1 F 28 + 1 M 27), clinical data unavailable.

The remainig of the article discusses 'D222E' [H3 HA D225E] and oseltamivir resistance cases:

http://translate.google.com/translate?j ... auto&tl=en

A 70-year navarro a mutation of the influenza A virus 'H275Y'

- The Institute of Health Carlos III de Madrid received notification of resistance to Tamiflu
although the incidence [of h1n1] is only about 29 cases per 100,000 population


The Carlos III Health Institute has reported in its latest report a new case of mutation 'H275Y', associated with resistance to oseltamivir, the antiviral used to combat cases of influenza A and whose laboratory marketed under the name Tamiflu .

This is a man of 70 years of Navarre, symptoms began on 30 October 2009. With this one, so far have been detected in Spain three cases with the presence of this mutation, one in Catalonia, one in the Basque Country and the latter, in Navarre.

As for the mutation 'D222G', first detected in Norway and has already caused two deaths in Spain (one in Catalonia and Andalusia), so far seven cases have been detected, distributed in: Andalusia (3) , Cataluña (2), Castilla La Mancha (1) and Galicia (1). Variant 'D222E' Surveillance Network recorded 40 cases.


[...]

[There has been a small uptick in cases in several communities]

Thus, according to data compiled by Sentinel Healthcare System, the fastest growing community where the incidence of the virus is Castile and Leon (from 11.15 to 43.56 cases per 100,000 population) followed by Baleares ( where the previous week was 6.51 cases per 100,000 and this week is 28.37), Melilla (with a rate of 42.94 cases per 100,000 compared with 28.18 the previous week), Ceuta (which presented no cases and this week is 12.5 per 100,000) and Aragon (which increased from 8.5 to 15.99 cases per 100,000).

[...]
One week, flu activity continues to fall-this time 20 per cent less than 37 cases per 100,000 the previous week-and at levels typical of the pre-epidemic, far from the highest peak cases since the start of influenza A in Spain, 372.70 cases per 100.0000 inhabitants recorded in mid-November.

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Still reporting 2 for deaths, so it appears that the 70 year old man recovered. Not stated.

Spain reported 5 more D225G mutations this week:

10 total - Andalusia (3), Catalonia (2), Castilla La Mancha (1), Galicia (1) and Basque Country (3)

Spain reported 6 more D222E cases this week (now 40 total)

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[same post @ Spain]

Spain flu surveillance report

week 52
http://www.isciii.es/htdocs/centros/epi ... rn5209.pdf



google translate from Spanish to English,

page 4 discusses mutations - With regard to mutations associated with resistance to oseltamivir, no new case found this week. (two previously reported in Catalonia and the Basque Country, symptoms that began on Nov 5th and 11th.


In week 52/2009 was reported the detection of five mutations D222G, three of them in the Basque region and two in Andalusia, as the more data is obtained CNM will develop a more complete report. This mutation has been detected in other countries as being trying to document the data to be reported to WHO, since its significance functional is not defined. So far Spain have been detected in 10 case presenting distributed mutation D222G:

Andalusia (3), Catalonia (2), Castilla La Mancha (1), Galicia (1) and Basque Country (3)

There is an increase in the number of viruses detected in cases from different regions have the mutation D222E. Since last week the CNM has detected this mutation in six patients in addition to the 34 identified last week.

Commentary

http://www.recombinomics.com/News/01161 ... Spain.html

Story became very popular very quickly

http://www.newsnow.co.uk/h/Hot+Topics/F ... lu?type=ts