Rhiza Labs FluTracker Forum

12/19/09

http://translate.google.com/translate?j ... l=tr&tl=en

translated from Turkish ....

In Germany, the first cases resistant Tamiflu'ya

Germany used in the treatment of swine influenza drug Tamiflu has not responded to the first swine flu case was detected. . According to a statement issued from Münster University Hospital, "has become drug resistant virus."

Münster University Hospital, Georg Peters, President of Institute of Microbiology, "swine flu a patient is hospitalized with a diagnosis applied to the therapy given to patients within the scope of the Tamiflu drug did not create any impact is determined" he said.

Cause any effect in a statement not Tamiflu'nun virus drug resistance is a sign that the win was specified.

Patients treated with Tamiflu in question before and kept under observation during the disease course were analyzed. Microbiology expert Georg Peters, "Review of the virus as a result, now in hand the few drugs used for the treatment of swine flu in a short time has become resistant" said detected.

[...]

Germany is at it's lowest level of ILI for this time of year since Google started keeping track. Several other countries in Europe too.

New strains emerge when the viral level is low. That is how H274Y went to 100% in seasonal flu. It was established at 100% in the southerm hemisphere in 2008 and then went to 100% in the northern hemisphere in 2008/2009.
This is evolution in action (report's requests for a "pandemic is over" statement notwithstanding).

That makes sense. It's why I think the Spring Wave happened the same week on opposite sides of the world, despite it getting warmer. The seasonal flu was killed off enough that it could take over. The being immune to flu for a few weeks after hit by any strain, thing that crowds the other out.

Well, we'll be able to hear a pin drop in a few weeks.

For the first time in Germany when swine flu patients - a ten year old and a 31-year-old man - resistance to the influenza drug Tamiflu has been demonstrated.

Both had come with pre-existing conditions and a "weak defense" to the University Hospital of Munster, said the clinic on Friday. They were already infected with swine flu in the reception.

Tamiflu resistance already exist in other countries such as Norway, Britain and Denmark have been detected. Insensitivity to the drug are also found in the seasonal flu - experts believe it is therefore not surprising that even with the swine flu comes to resistance formation. At the recent therapeutic recommendations would not affect the cases in Munster, said on Friday at the Robert Koch Institute. It will monitor the development.

Because Tamiflu in patients treated in Munster had not struck, they were treated with the alternative anti-influenza drug Relenza. "For the child we have the H1N1 Done respirator" is now under control, the man is, "said Prof. Georg Peters, Director of the Institute for Clinical Microbiology. The condition of the 31-year-old was bad, but stable.

Peters believes that a further increase with the expected wave of swine flu, the number of resistances. "Probably there are already more resistance in Germany, they were just not yet proven. The story is not over yet. "However, it is currently assumed in the majority of circulating viruses from a sensitivity to Tamiflu. The drug also works in most cases, even to the pathogen.

Given the low Impfzahlen in Germany, the experts warned against underestimating the risks or downplay. Vaccination is the best protection, even before the formation of resistance, said the medical director of the University Hospital, Prof. Norbert Roeder. "Otherwise, the weapons we have, at some blunt."

http://www.halternerzeitung.de/Erste-Ta ... 321,765993

In the past week at the University Hospital Münster (UKM), Germany for the first time the disease heitsverläufe two patients have been documented, which appears to confer resistance to the previously developed normally used against the swine flu drug "Tamiflu". "The resistance means that altered the virus during treatment with Tamiflu has, "said Dr. George Peters, director of UKM Institute for Clinical Microbiology. The senior consultant virologist Professor Joachim Kühn (UKM Institute for Medical Microbiology) and his colleagues were able to say before the patients to watch during and after the treatment with Tamiflu. "These results demonstrated how fast it can develop a resistance to the few currently available drugs."

CEO and medical director of UKM, Prof. Dr. Norbert Roeder reminded once again to the responsibility of physicians and patients: "No one should lightly take Tamiflu to himself." This drug should be given only those H1N1-infected patients, which demonstrated the virus and was also a chronic disease have. "As before, we recommend very strongly to vaccination, since only thus can a protection," said Roeder. "Despite the current news on the abatement of the new infections, the flu should not be taken lightly." At UKM vaccinated now around 2770 people: "We have vaccinated at UKM, about half of the medical staff that has patient contact. This is one in North Rhine-Westphalia comparison extremely good rate. "

The microbiologist Peter Kuhn, and continues to place itself in this perspective that went through most of the Germans have no contact - either by a disease or has had the vaccine - the flu. "For these people, who from a microbiological point of view," immunologic gap "that would mean a vaccine offers good protection." For no one can say today how to develop the H1N1 virus further. "The worst scenario would be if we had the next winter no more effective drugs against swine flu, and a larger number of people would suffer."

http://www.klinikum.uni-muenster.de/ind ... &tx_ttnews[tt_news]=298&tx_ttnews[backPid]=30&cHash=27d815d8fc

Commentary

http://www.recombinomics.com/News/12200 ... rmany.html

2 resistant cases reported in mid-December .... still 2 found as of article 1/8/2010


http://www.aerztezeitung.de/medizin/kra ... stent.html


Swine influenza viruses are often resistant to Tamiflu ®

H1N1 viruses are sensitive to oseltamivir (Tamiflu ®). Resistance have been found only in isolated cases.

MUNSTER (hub). "Initial resistance to Tamiflu ® in Germany," it was mid-December through the media. The university hospital in Muenster was specially invited to a press conference. As a result, even readers of the "Doctors newspaper asked" whether oseltamivir could still be ordered. The answer is clearly "yes." Because the resistance is anecdotal.



That does not always favor the selection pressure through drug regulation, the development of resistance, for example, shows the seasonal H1N1 virus: This has a resistant variant of it although little Oseltamivir was prescribed. It was created a mutation that has maintained independently of the Tamiflu ® for resistance to a more fit variant. Only then can we explain the fact that the variation within a few months had established worldwide, said Dr. Michael Pfleiderer of the Paul Ehrlich Institute in conversation with the "Doctors newspaper as early as summer 2009. The possible selective advantage of resistance was not decisive. "This was not an event due to an overwhelming selection pressure, but a spontaneous event," said Pfleiderer then.

An important tip called the medical director of the Munster University Hospital, Professor Norbert Roeder, helped organize in December: "Vaccination is the best protection, even against resistance formations. Otherwise, the weapons we have, at some butt." [as translated with google]