Cases of Tamiflu (or other anti-viral resistance)

niman · **Posted:** Mon Aug 24, 2009 3:41 am

Updated list fro A1231G:

gb|GQ499337.1| Influenza A virus (A/Washington/28/2009(H1N1))... 40.1 0.047
gb|GQ499335.1| Influenza A virus (A/Washington/29/2009(H1N1))... 40.1 0.047
gb|GQ465707.1| Influenza A virus (A/Canada-NS/RV1565/2009(H1N... 40.1 0.047
gb|GQ465699.1| Influenza A virus (A/Canada-NS/RV1554/2009(H1N... 40.1 0.047
gb|GQ465698.1| Influenza A virus (A/Canada-NS/RV1551/2009(H1N... 40.1 0.047
gb|CY044165.1| Influenza A virus (A/Mexico/48N/2009(H1N1)) se... 40.1 0.047
gb|GQ433898.1| Influenza A virus (A/Jiangsu/1/2009(H1N1)) seg... 40.1 0.047
gb|GQ377086.1| Influenza A virus (A/Oregon/07/2009(H1N1)) seg... 40.1 0.047
gb|GQ377074.1| Influenza A virus (A/Washington/18/2009(H1N1))... 40.1 0.047
gb|GQ377048.1| Influenza A virus (A/Washington/17/2009(H1N1))... 40.1 0.047
gb|GQ338393.1| Influenza A virus (A/Washington/08/2009(H1N1))... 40.1 0.047
gb|GQ338371.1| Influenza A virus (A/Washington/10/2009(H1N1))... 40.1 0.047
gb|GQ323562.1| Influenza A virus (A/Florida/10/2009(H1N1)) se... 40.1 0.047
gb|GQ323543.1| Influenza A virus (A/Washington/09/2009(H1N1))... 40.1 0.047
gb|GQ323507.1| Influenza A virus (A/Washington/14/2009(H1N1))... 40.1 0.047
gb|GQ223445.1| Influenza A virus (A/GuangzhouSB/01/2009(H1N1)... 40.1 0.047
gb|GQ221696.1| Influenza A virus (A/GuangzhouSB/01/2009(H1N1)... 40.1 0.047
gb|CY040890.1| Influenza A virus (A/Mexico/47N/2009(H1N1)) se... 40.1 0.047
gb|GQ150333.1| Influenza A virus (A/Christchurch/2/2009(H1N1)... 40.1 0.047
gb|GQ132158.1| Influenza A virus (A/Canada-NS/RV1536/2009(H1N... 40.1 0.047
gb|GQ132154.1| Influenza A virus (A/Canada-NS/RV1538/2009(H1N... 40.1 0.047
gb|GQ122098.1| Influenza A virus (A/Christchurch/2/2009(H1N1)... 40.1 0.047

niman · **Posted:** Mon Aug 24, 2009 6:25 am

Commentary

http://www.recombinomics.com/News/08240 ... Match.html

wotan · **Posted:** Mon Aug 24, 2009 11:18 am

Taiwan:

http://english.rti.org.tw/Content/GetSingleNews.aspx?ContentID=85237

The rapid progression of her illness despite the administration of anti-viral medication raises fears that she might have a strain of H1N1 that has developed some resistance to the medication. CDC Director Steve Kuo explains.

"This is why we have to have a special investigation of this death," said Kuo, "we need to retrace the steps that lead up to the fatality to figure out whether the drug was given too slowly or whether the virus was able to resist the medication."

wotan · **Posted:** Thu Aug 27, 2009 10:44 pm

I think this is new. Tamiflu resistance confirmed in California?
http://www.cdph.ca.gov/programs/vrdl/Documents/InfluenzaUpdate082009.pdf

Quote:

During this week, the CDPH Viral and Rickettsial Diseases Laboratory detected a specimen with the H275Y resistance mutation (associated with oseltamivir resistance); the result was confirmed by the CDC. This is the first time that this mutation has been detected by the VRDL and provides strong evidence for the importance of enhanced surveillance for antiviral resistance testing. The specimen was obtained from a hospitalized patient in Northern California. To date, 308 specimens have been tested at VRDL for the resistance mutation; all but one have tested negative for the mutation. VRDL and CDC will continue prospective antiviral resistance testing from a sampling of pandemic (H1N1) 2009 influenza viruses through the summer and the 2009-10 influenza season.

niman · **Posted:** Fri Aug 28, 2009 4:22 am

wotan wrote:

I think this is new. Tamiflu resistance confirmed in California?
http://www.cdph.ca.gov/programs/vrdl/Documents/InfluenzaUpdate082009.pdf

Quote:

During this week, the CDPH Viral and Rickettsial Diseases Laboratory detected a specimen with the H275Y resistance mutation (associated with oseltamivir resistance); the result was confirmed by the CDC. This is the first time that this mutation has been detected by the VRDL and provides strong evidence for the importance of enhanced surveillance for antiviral resistance testing. The specimen was obtained from a hospitalized patient in Northern California. To date, 308 specimens have been tested at VRDL for the resistance mutation; all but one have tested negative for the mutation. VRDL and CDC will continue prospective antiviral resistance testing from a sampling of pandemic (H1N1) 2009 influenza viruses through the summer and the 2009-10 influenza season.

Yes, this is new and of course northern California (San Francisco) is the origin of the case in Hong Kong where the traveler had a mild case and recivered with no Tamiflu resitance. It is not clear if this is the first hospitalized patient in the US who is not immunocompromised, since the above doesn't give details on the patient.

The UK is also listing a summary of WHO notified cases, and they show 4 from Japan, which is an increase of one over the cases I know of.

niman · **Posted:** Fri Aug 28, 2009 4:35 am

WHO has also been notified of 12 cases of oseltamivir resistant virus. These isolates have a mutation in the neuraminidase (referred to as H275Y) that confers resistance to oseltamivir, though the viruses remain sensitive to zanamivir. Of these 8 have been associated with oseltamivir post exposure prophylaxis, one with treatment of uncomplicated illness, and two have been from immunocompromised patients receiving oseltamivir treatment. These isolated cases have arisen in different parts of the world (Japan 4, USA 2, China, Hong Kong SAR China 2, and 1 in Denmark, Canada, Singapore and China), and there are no epidemiological links between them. There is also no evidence of onward transmission from these cases.

http://www.who.int/csr/don/2009_08_21/en/index.html

niman · **Posted:** Fri Aug 28, 2009 7:47 am

Commentary

http://www.recombinomics.com/News/08280 ... 4Y_CA.html

wotan · **Posted:** Fri Aug 28, 2009 9:11 am

niman wrote:

wotan wrote:

I think this is new. Tamiflu resistance confirmed in California?
http://www.cdph.ca.gov/programs/vrdl/Documents/InfluenzaUpdate082009.pdf

Quote:

During this week, the CDPH Viral and Rickettsial Diseases Laboratory detected a specimen with the H275Y resistance mutation (associated with oseltamivir resistance); the result was confirmed by the CDC. This is the first time that this mutation has been detected by the VRDL and provides strong evidence for the importance of enhanced surveillance for antiviral resistance testing. The specimen was obtained from a hospitalized patient in Northern California. To date, 308 specimens have been tested at VRDL for the resistance mutation; all but one have tested negative for the mutation. VRDL and CDC will continue prospective antiviral resistance testing from a sampling of pandemic (H1N1) 2009 influenza viruses through the summer and the 2009-10 influenza season.

Yes, this is new and of course northern California (San Francisco) is the origin of the case in Hong Kong where the traveler had a mild case and recivered with no Tamiflu resitance. It is not clear if this is the first hospitalized patient in the US who is not immunocompromised, since the above doesn't give details on the patient.

The UK is also listing a summary of WHO notified cases, and they show 4 from Japan, which is an increase of one over the cases I know of.

This report was released silently and apparently after hours yesterday. All the more interesting, this is California's week 32 surveillance. CDC's week 32 surveillance had the 2 in Washington and the announcement of 2 more in NC. The CDC has not updated their week 32 surveillance to reflect this report. Furthermore, I have seen no news coverage of this as of yet.

If I read it correctly, California reported 0 cases of seasonal flu in week 32.

wotan · **Posted:** Fri Aug 28, 2009 4:42 pm

http://www.cdc.gov/flu/weekly/

The CDC is reporting 6 cases of Tamiflu resistance but I can only account for 5 so far. 2 in Washington, 2 in NC, 1 in CA. Five of the 6 were receiving Tamiflu treatment, the sixth is being researched.

wotan · **Posted:** Fri Aug 28, 2009 4:46 pm

wotan wrote:

http://www.cdc.gov/flu/weekly/

The CDC is reporting 6 cases of Tamiflu resistance but I can only account for 5 so far. 2 in Washington, 2 in NC, 1 in CA. Five of the 6 were receiving Tamiflu treatment, the sixth is being researched.

The table says 6 cases but the text says 7:

Quote:

The majority of 2009 influenza A (H1N1) viruses are susceptible to the neuraminidase inhibitor antiviral medication oseltamivir, however rare sporadic cases of oseltamivir resistant 2009 influenza A (H1N1) viruses have been detected worldwide, including seven viruses in the United States. All tested viruses retain their sensitivity to the other neuraminidase inhibitor zanamivir. Additional information on antiviral recommendations for treatment and chemoprophylaxis of 2009 influenza A (H1N1) infection is available at http://www.cdc.gov/h1n1flu/recommendations.htm All 2009 influenza A (H1N1) viruses tested to date are resistant to the adamantane antiviral medications, amantadine and rimantadine. Antiviral treatment with either oseltamivir or zanamivir is recommended for all patients with confirmed, probable or suspected cases of 2009 influenza A (H1N1) virus infection who are hospitalized or who are at higher risk for seasonal influenza complications.

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