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PostPosted: Tue Sep 01, 2009 5:48 am 
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Hogweed wrote:
niman wrote:
the A193T involved the same position that was linked to the fixing of adamantine resistance, MP S31N, in H3N2. In H3N2, the key change was S193F and position 193 in swine H1N1 is "S". Moreover, the other key H3N2 change was at position 225 (D225N), and D225E has been noted previously in some swine H1N1 isoaltes (including the fit Hong Kong ex-San Francisco isolate).

You make some mention of problems with vaccines associated with these and similar changes in your paper. Also in your commentary http://www.recombinomics.com/News/03240 ... lures.html dating back to March you said

Quote:
Thus, the failure to note the significant H1N1 changes last season and this season, in association with H274Y hitch-hiking, and in the selection of the vaccine target for next season, is cause for concern.


Can you comment on these concerns with relation to the current swine H1N1 vaccine under development?

The A193T chnage was also associate with flanking chnages at positions 187, 189, and 196 and some of these associated changes were linked to vaccine resistance. Thus, small chnages in this region can have significant effects on vaccine efficacy,and since such chnages are acquired via recombination, some of the seasonal H1N1 acquisitions could also jump to swine H1N1.

These jumps are the concern. There is a large reservoir in co-circulationg H1N1, also locations, such as Hong Kong are repotrting H3N2 co-circulating with swine H1N1, with little seasonal H1N1 or infleunza B. However, the rapid spread of H1N1 in humans allows for a wide range on co-infections, and jumps back to swine and turkeys increases the number and variety of co-infections.

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PostPosted: Tue Sep 01, 2009 5:50 am 
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niman wrote:
wotan wrote:
Texas has finally released week 32 surveillance and. as suspected, there are two cases of Tamiflu resistance.

Code:
nfluenza A/H1 (novel)      5      2 (40%)      0 (0)      5      5 (100%) 

Looks like the "denied" cases. As originally noted, two cases at the same time in very different locations are cause for concern.

http://www.recombinomics.com/News/08040 ... pread.html

http://www.dshs.state.tx.us/idcu/diseas ... entFlu.pdf

Original (Aug 3) description of Tamiflu resistance in Texas

A strain of swine flu that is resistant to treatment with the drug Tamiflu has been discovered near the US-Mexican border, the Pan-American Health Organization (PAHO) said on Monday.

"We have found resistance to Tamiflu on the border. We have observed some cases, few to be sure, in El Paso and close to McAllen, Texas," said Maria Teresa Cerqueira, head of the local PAHO office.

Cases of A(H1N1) that were resistant to the anti-viral medicine have now been found in the United States, Canada, Denmark, Hong Kong and Japan.

Experts gathered in La Jolla, California on Monday to discuss the response to the outbreak, said the resistance was likely due to overuse of antivirals like Tamiflu.

"In the United States Tamiflu is sold with a prescription, but in Mexico and Canada it is sold freely and taken at the first sneeze. Then, when it is really needed, it doesn't work," said Cerqueira.

Roche, the manufacturer of Tamiflu, has said it expects a 0.5 percent rate of case resistance based on clinical trials.

Cerquiera said one patient diagnosed with a Tamiflu-resistant strain had been treated with Zanamivir -- an anti-viral made by GlaxoSmithKline -- and another was given no alternative medication. Both survived.

http://www.google.com/hostednews/afp/ar ... nYOs5DuTtA

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PostPosted: Tue Sep 01, 2009 6:54 am 
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Commentary

http://www.recombinomics.com/News/09010 ... pread.html

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PostPosted: Thu Sep 03, 2009 4:14 pm 
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someone asked for it in chat, so here is a paper how/when Amantadine
resistance developed in European swine which then gave M (segment 7) to mexflu

http://vir.sgmjournals.org/cgi/content/full/90/4/900



> As there are no indications that pigs ever have been treated with
> amantadine in Europe, the emergence of amantadine resistance
> has very likely a natural cause.

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PostPosted: Fri Sep 04, 2009 12:17 pm 
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The week 34 fluview now reports 9 cases of Tamiflu resistance in the US:

Quote:
‡Three state public health laboratories perform antiviral resistance testing and report their results to CDC. An additional two oseltamivir resistant 2009 influenza A (H1N1) viruses have been identified by these laboratories, bringing the total number to nine.


It was in a footnote, and not in the main data table.

It is all H274Y. Sure doesn't sound random or we should see some of the other polymorphisms that convey Tamiflu resistance.

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PostPosted: Fri Sep 04, 2009 12:33 pm 
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wotan wrote:
The week 34 fluview now reports 9 cases of Tamiflu resistance in the US:

Quote:
‡Three state public health laboratories perform antiviral resistance testing and report their results to CDC. An additional two oseltamivir resistant 2009 influenza A (H1N1) viruses have been identified by these laboratories, bringing the total number to nine.


It was in a footnote, and not in the main data table.

It is all H274Y. Sure doesn't sound random or we should see some of the other polymorphisms that convey Tamiflu resistance.

Well, if it is a state performing there own analysis, its not TX. Could be CA. Not sure who the other two states are.

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PostPosted: Fri Sep 04, 2009 12:52 pm 
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:hello: dina624.

This is a very interesting statement from Florida:

http://fluboard.rhizalabs.com/forum/viewtopic.php?p=3813#p3813

Quote:
Virtually all infections due to the new virus are caused by strains that are sensitive to Tamiflu and Relenza.

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PostPosted: Fri Sep 04, 2009 12:58 pm 
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niman wrote:
wotan wrote:
The week 34 fluview now reports 9 cases of Tamiflu resistance in the US:

Quote:
‡Three state public health laboratories perform antiviral resistance testing and report their results to CDC. An additional two oseltamivir resistant 2009 influenza A (H1N1) viruses have been identified by these laboratories, bringing the total number to nine.


It was in a footnote, and not in the main data table.

It is all H274Y. Sure doesn't sound random or we should see some of the other polymorphisms that convey Tamiflu resistance.

Well, if it is a state performing there own analysis, its not TX. Could be CA. Not sure who the other two states are.

CA is still showing one case. NY also does their own antiviral testing (using Wadsworth). Of course NY hasn't updated their seasonal flu site since April because its not flu season! Still working on the third state that does their own antiviral testing.

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PostPosted: Fri Sep 04, 2009 1:02 pm 
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wotan wrote:
:hello: dina624.

This is a very interesting statement from Florida:

http://fluboard.rhizalabs.com/forum/viewtopic.php?p=3813#p3813

Quote:
Virtually all infections due to the new virus are caused by strains that are sensitive to Tamiflu and Relenza.

I think that is a "general" statement. Two of the three states doing their own testing are CA and NY. The third state should have its own data for seasonal flu last season (and should have pandmeic H1N1 data, as seen in CA, but I haven't found a NY update - just data from the past flu season, were NY did its own testing through Wadsworth).

I have to check out MD and WI, which may be candidates - JCVI is in MD.

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PostPosted: Fri Sep 04, 2009 1:21 pm 
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niman wrote:
wotan wrote:
:hello: dina624.

This is a very interesting statement from Florida:

http://fluboard.rhizalabs.com/forum/viewtopic.php?p=3813#p3813

Quote:
Virtually all infections due to the new virus are caused by strains that are sensitive to Tamiflu and Relenza.

I think that is a "general" statement. Two of the three states doing their own testing are CA and NY. The third state should have its own data for seasonal flu last season (and should have pandemic H1N1 data, as seen in CA, but I haven't found a NY update - just data from the past flu season, were NY did its own testing through Wadsworth).

I have to check out MD and WI, which may be candidates - JCVI is in MD.

Looks like WI. They had no positives out of 50 tested through week 33. No week 34 data up yet.

Thus, it looks like the two new cases are in CA, NY, or WI and the state(s) with resistance have not yet posted yet.

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Last edited by niman on Fri Sep 04, 2009 7:23 pm, edited 1 time in total.

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