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PostPosted: Sun Aug 30, 2009 2:06 pm 
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wotan wrote:
I can't account for two of the cases of Tamiflu resistance. Last week the CDC was reporting 4. Today it is 7. One of the new cases should be the one from California.

Texas has still not released their week 32 surveillance. A few weeks back there were reports of at least 2 cases of Tamiflu resistance in Texas that were later denied....

I think the one in California is fit (no documentarion of prior Tamiflu use), which of course is a problem.

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PostPosted: Sun Aug 30, 2009 3:29 pm 
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Quote:
An increasing number of countries, including some in Asia, are now reporting Tamiflu resistant H1N1 virus. The worrying development,
according to WHO, has seen 12 countries including China and Singapore. India has not reported the mutation in the virus so far.

The changes in the virus reported in samples are making these strains of swine flu resistant to oseltamivir or Tamiflu - the antiviral of choice globally. Such cases have also been found in Japan, US, Hong Kong, Denmark and Canada.
...


http://timesofindia.indiatimes.com/NEWS ... 952430.cms


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PostPosted: Mon Aug 31, 2009 5:21 am 
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Commentary

http://www.recombinomics.com/News/08310 ... A_Fit.html

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PostPosted: Mon Aug 31, 2009 8:08 am 
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Dr Niman,

Yourself and others have highlighted A193T as important in conjunction with H274Y in seasonal H1N1. Can you comment on any implications this might (or might not) have in regard to novel swine H1N1?


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PostPosted: Mon Aug 31, 2009 9:34 am 
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Hogweed wrote:
Dr Niman,

Yourself and others have highlighted A193T as important in conjunction with H274Y in seasonal H1N1. Can you comment on any implications this might (or might not) have in regard to novel swine H1N1?

I suspect you have noticed a relationship between swine H1N1 and H3N2 human seasonal flu. As noted previously

http://precedings.nature.com/documents/2832/version/1

the A193T involved the same position that was linked to the fixing of adamantine resistance, MP S31N, in H3N2. In H3N2, the key change was S193F and position 193 in swine H1N1 is "S". Moreover, the other key H3N2 change was at position 225 (D225N), and D225E has been noted previously in some swine H1N1 isoaltes (including the fit Hong Kong ex-San Francisco isolate)

http://www.recombinomics.com/News/07140 ... Swine.html

Thus, the two wild type positions in H3N2 antivral resistance match positions in H1N1 (positions 193 and 225). Moreover, swine H1N1 has an H3N2 PB1 and has already acquired the MP resistance change, S31N, so the acquisitions seen in seasonal H3N2 may highlight significant future changes in swine H1N1 associated with dominance.

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PostPosted: Mon Aug 31, 2009 3:04 pm 
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Texas has finally released week 32 surveillance and. as suspected, there are two cases of Tamiflu resistance.

Code:
nfluenza A/H1 (novel)      5      2 (40%)      0 (0)      5      5 (100%) 

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PostPosted: Mon Aug 31, 2009 3:09 pm 
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wotan wrote:
Texas has finally released week 32 surveillance and. as suspected, there are two cases of Tamiflu resistance.

Code:
nfluenza A/H1 (novel)      5      2 (40%)      0 (0)      5      5 (100%) 

Looks like the "denied" cases. As originally noted, two cases at the same time in very different locations are cause for concern.

http://www.recombinomics.com/News/08040 ... pread.html

http://www.dshs.state.tx.us/idcu/diseas ... entFlu.pdf

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PostPosted: Mon Aug 31, 2009 4:36 pm 
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Commentary

http://www.recombinomics.com/News/08310 ... irmed.html

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PostPosted: Mon Aug 31, 2009 5:52 pm 
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niman wrote:
the A193T involved the same position that was linked to the fixing of adamantine resistance, MP S31N, in H3N2. In H3N2, the key change was S193F and position 193 in swine H1N1 is "S". Moreover, the other key H3N2 change was at position 225 (D225N), and D225E has been noted previously in some swine H1N1 isoaltes (including the fit Hong Kong ex-San Francisco isolate).

You make some mention of problems with vaccines associated with these and similar changes in your paper. Also in your commentary http://www.recombinomics.com/News/03240 ... lures.html dating back to March you said

Quote:
Thus, the failure to note the significant H1N1 changes last season and this season, in association with H274Y hitch-hiking, and in the selection of the vaccine target for next season, is cause for concern.


Can you comment on these concerns with relation to the current swine H1N1 vaccine under development?


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PostPosted: Tue Sep 01, 2009 12:10 am 
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http://timesofindia.indiatimes.com/NEWS ... 956574.cms

Quote:
AHMEDABAD: Officials of Ahmedabad Municipal Corporation have cast aside fears of H1N1 virus becoming Tamiflu-resistant and will continue
administering the medicine to patients. This after some countries reported mutation of the virus.

"Not a single case in the country has reported mutation so far. Tamiflu treatment has been given to patients which are under category B and C as per guidelines laid down by health ministry," said a senior health official. Till now, city has reported 72 H1N1 positive cases. "On an average, around 8 to 10 contacts of the infected person are regularly monitored and given Tamiflu tablets," added the official.

According to WHO, the worrying development which has been seen in 12 countries, including China and Singapore is of Tamiflu resistant virus. Such cases have also been found in Japan, US, Hong Kong, Denmark and Canada.

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